Information for UK-based patients who have been prescribed RYBELSUS®

Stay informed about possible side effects

Like all medicines, RYBELSUS® may cause side effects, although not everybody gets them

Please always ensure that you read the Patient Information Leaflet↗ accompanying your medication for further information before you take RYBELSUS®. Please refer to the Patient Information Leaflet↗ for full details about possible side effects

Talk with your doctor or nurse if you experience any side effect, or if you have any questions or concerns

Very common side effects (may affect more than 1 in 10 people) with RYBELSUS® are:

  • feeling sick (nausea) – this usually goes away over time
  • diarrhoea – this usually goes away over time
  • low blood sugar (hypoglycaemia) when this medicine is used with medicines that contain a sulfonylurea or insulin. Your doctor may reduce your dose of these medicines before you start using RYBELSUS®.

The warning signs of low blood sugar may come on suddenly. They can include: cold sweat, cool pale skin, headache, fast heartbeat, feeling sick (nausea) or very hungry, changes in vision, feeling sleepy or weak, feeling nervous, anxious or confused, difficulty concentrating or shaking. Your doctor will tell you how to treat low blood sugar and what to do if you notice these warning signs

If you experience nausea, here are some tips to help manage it:

Try to

  • Eat smaller portions more regularly
  • Eat slowly
  • Stay hydrated. When nausea appears, drinking cold water can help
  • Listen to your body. Stop eating at the first sign of fullness


•   Fried or fatty foods
•   Overly sweet or spicy foods
•   Intake of a large amount of fibrous food
     in a single meal; distribute them
     throughout the day
•   Drinking alcohol and smoking cigarettes

Dosing plan

Take your dose as prescribed by your doctor


Get answers to commonly asked questions about RYBELSUS®

UK21RYB00235 | November 2021